The aim of this study was to investigate whether general anesthetic agents change erythrocyte sedimentation rate (ESR) affecting erythrocytes’ shape and. Türkmen K, Tanbul HZ, Toker A, et al. The Relationship between Oxidative Stress , Inflammation, and Atherosclerosis in Renal Transplant and. (SDBH) olgularında enfeksiyon olmaksızın, eritrosit sedimantasyon hızı (ESH) ve C- reaktif .. A, Demirtas L, Turk S, Tonbul HZ: Platelet-to-lymphocyte ratio.
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End stage renal disease ESRD has a high worldwide prevalence and incidence. Peritonitis is one of the leading causes of hospitalization in peritoneal dialysis patients. Although inflammatory markers show increased inflammatory responses, cellular immune response was decreased in ESRD patients.
Leptin is an adipocyte-derived hormone that has activity in energy, nutrition and immune system. Forty-one ESRD patients, who were sedimentaxyon at least 12 months of peritoneal dialysis therapy, were included in the study. Serum leptin level, WBC count, C-reactive protein, erythrocyte sedimentation rate and biochemical markers were measured.
Patients with active viral or bacterial infection, malignancy, inflammatory disease, immunosuppressive medication users were all excluded from the study. Age and sex-matched healthy control group was included in the study only for their leptin levels.
The measured mean serum leptin level of the patient group was statistically significantly higher than control group The calculated mean peritonitis incidence was 0. The number of peritonitis attack was significantly correlated with duration of peritoneal dialysis, body mass index BMIage and presence of cardiovascular disease. We detected that ESRD patients have higher serum eritrositt levels compare to healthy adults.
Number of peritonitis attack and peritonitis incidence was significantly correlated with the duration of PD, BMI and sex. Chronic renal failure has a high worldwide prevalence and incidence.
Marmara Ãniversitesi TÄ±p FakÃ¼ltesi Dergisi – Marmara Medical Journal –
Long-term dialysis patients have high morbidity and mortality rates. Associated risk factors were age, gender, duration of dialysis, concomitant diseases, presence of complication and inflammatory diseases. Hospitalization requirement is more frequent and duration is sedimetasyon in dialysis patients especially in patients with comorbid infection and cardiovascular disease [ 1 ].
Peritonitis is one of the leading causes of hospitalization in peritoneal dialysis patients [ 2 ]. Immune system functions were affected in uremia. Inflammatory markers show an increased inflammatory response however cellular immune response was decreased in ESRD patients [ 3 ]. Increased inflammation was accused for increasing cardiovascular morbidity and mortality of ESRD patients [ 4 ].
Leptin is a protein for body eritroskt that has a regulatory role controlling apatite and energy expenditure. Serum leptin level increases in obesity, hyperglycaemia and uremia due to decreased renal excretion erirosit 56 ]. In this study, patients were selected from the sedimentawyon clinic of Ataturk University Medical Faculty Nephrology Department between August and November The study was approved by the local ethical committee.
Informed consent of the patient and control groups was collected from the previous study. Forty-one ESRD patients 17 male, 24 femalewho were on least 12 months of peritoneal dialysis treatment, were included in the study. Patients with known sedimnetasyon viral or bacterial infection, malignancy, inflammatory disease and immunosuppressive medication users were all excluded from the study.
Blood samples for leptin, whole blood count, C reactive protein CRPErythrocyte sedimentation rate ESRglucose, sedimentawyon and calcium Caalbumin were collected from forearm venipuncture in the morning. Whole blood count and all other laboratory measurements except leptin were done within 30 to 60 min after sampling. Leptin analysis was performed according to manufacturer manuals. Samples for serum leptin were centrifuged at rpm for 15 min within 30 minutes after collection.
Anti-human leptin antibody added and incubated for 60 min. Plates efitrosit washed three times using the TBS solution.
The Role of Prohepcidin and Hepcidin in Anemia Associated with Behçet s Disease
The plates were washed using the TBS solution. Absorbance was analyzed at nm 30 min after stop solution added. Patient characteristics, duration of peritoneal dialysis monthspresence of any concomitant diseases, age, gender, sex, number of peritonitis attack, if available cultured microorganism, etiologic cause of ESRD, body mas index, erythrocyte sedimentation rate, C-reactive protein level, white blood cell count, formulation of subgroups of white blood cell neutrophil, lymphocyteneutrophil to lymphocyte ratio, blood glucose, calcium, phosphate and albumin levels were all recorded.
Parametric tests aedimentasyon applied to data with normal distribution, whereas nonparametric tests were applied to data with non-normal distribution. Chi-square tests were applied for categorical variables. Fort-one ESRD patients, who were on least month therapy of peritoneal dialysis, were included in the study serving as the patient group and 30 healthy subjects were included in the study serving as the control group.
Characteristic properties of the patient group and sedimejtasyon of the results as means and standard deviation were given in Table 1. The frequencies of the primary causes of ESRD from reitrosit most common to rare among the patients were hypertension, diabetes mellitus DMglomerulonephritis, other causes, chronic interstitial sedimentazyon and polycystic renal disease Patients with known active viral or seddimentasyon infection, malignancy and inflammatory disease and immunosuppressive medication users were all excluded from the study because the investigated subject was also about inflammatory markers.
Because of this reason the patients with inflammation were excluded. The calculated peritonitis incidence was 0. Causative bacterial organism had isolated in Also, the number of peritonitis attack in female patients was statistically significantly detected higher than in males 1.
Mean blood glucose level of the patients was detected as Summary of the statistical results were given in Table 2. C- reactive protein; DM: The mean serum leptin level of the patient and control groups were Peritonitis is one of the most common complications of PD. Besides h the most frequent cause of hospitalization in patients receiving PD, it is also the major factor that leads to catheter loss. In this study, the number of peritonitis attack was detected significantly correlated with the duration of peritoneal dialysis, and BMI of peritoneal dialysis patients.
The accused risk factors that increase the risk of peritonitis were hypoalbuminemia, constipation, amyloidosis, surgical catheter replacement in PD, exit-site infection, immunosuppression and comorbid diseases [ 8 ]. Although PD has a survival advantage in the first 3—5 years of therapy compare to hemodialysis HDthis survival benefit was fade down in later years of follow up. Fibrosis and new vessel formation caused by chronic inflammation in peritoneal cavity via PD solutions leads to thickening of peritoneal membrane [ 9 ].
Both immune activation and immune deficiency were simultaneously present in end stage renal disease ESRD patients. Increased systemic inflammation leads to cardiovascular disease, cerebrovascular disease and mortality, and on the other hand immune deficiency leads to impaired response to vaccination and poor outcome of microbial infections [ 1011 ].
Soluble factors of immune system and their ancestry cellular parents comprise a complex set of interaction to defend the host against various diseases and conditions. The basic affair is the inflammations, which cause destruction and damage as a response to infection and tissue damage.
Leptin is an adipocyte-derived satiety hormone and also known as pro-inflammatory cytokine, which is a large-molecular weight protein. It is also noted as uremic toxin, because serum leptin concentrations are significantly higher in hemodialysis patients and it cannot be removed by hemodiafiltration. Leptin mediates an anti-apatite role via specific receptors in brain and peripheral tissue.
In our study we detected that serum leptin level in peritoneal dialysis patients were significantly higher than in control group. According to the subgroup analysis, we detected that patients with diabetes mellitus or hypertension as a primary cause of ESRD had significantly higher serum leptin level compare to other causes of ESRD.
Especially in chronic inflammatory diseases like diabetic nephropathy, cardiovascular disease, inflammatory bowel disease, colon and pancreas caner [ 1819 ]. PD is also a chronic inflammatory state and high basal inflammation even further increased in case of peritonitis. First of all, this is a cross-sectional study and it is not adequate to detect causes and response relationships accurately.
Although the number of the patients is adequate for a single study, the patient group is heterogenius for primary causes and further studies with larger number of patients are needed to detect differences between subgroups of ESRD.
In conclusion, we detected that ESRD patients have higher serum leptin levels compare to healthy adults. The number of peritonitis attack and peritonitis incidence was significantly correlated with duration of PD, BMI and sex of the patient. Further larger scaled prospective studies are required to reveal relation of lymphocyte functions and leptin in ESRD patients. Written informed consent was obtained from the patients who participated in this study.
Marmara Ãniversitesi TÄ±p FakÃ¼ltesi Dergisi – Marmara Medical Journal
No conflict egitrosit interest decleared by the authors. The authors decleared that this study has received no financial support. National Center for Biotechnology InformationU. Journal List Eurasian J Med reitrosit. Published online Aug Author information Article notes Copyright and License information Disclaimer.
Received Aug 24; Accepted Aug Leptin, neutrophil to Lymphocyte raito, peritonitis, peritoneal dialysis. Introduction Chronic renal failure has a high worldwide prevalence and incidence. Materials and Methods In this sedmentasyon, patients were selected from the outpatient clinic of Ataturk University Medical Faculty Nephrology Department between August and November Human serum leptin analysis Leptin analysis was performed according to eritrozit manuals.
Results Fort-one ESRD patients, who were on least eritrosut therapy of peritoneal dialysis, were included in the study serving as the patient group and 30 healthy subjects were included in the study serving as the control group.
Descriptive properties of the patient group and summary of the results. Open in a separate window. Summary of the statistical test results. Discussion Peritonitis is one of the most common complications of PD.
Footnotes Ethics Committee Approval: Dynamics of hospitalizations in hemodialysis patients: Microbiological profile of peritoneal dialysis peritonitis and predictors of hospitalization. Vitamin D deficiency, insulin resistance, serum adipokine,and leptin levels in peritoneal dialysis patients.
Body mass indes refenrence curves for the UK. Archives of Disases in Childhood. Turk J Med Sci. Peritoneal Dialysis Past, Present, and Future.
Iran J Kidney Dis.