Xanthogranulomatous cholecystitis (XGC) is an uncommon The files of the department of histopathology at the. Royal Hallamshire Hospital. Xanthogranulomatous cholecystitis is a rare inflammatory disease of in a review of 40 cases from the Armed Forces Institute of Pathology [3]. General. Uncommon ~ %. Approximately 2% in one series of gallbladders. May be confused (clinically) with gallbladder carcinoma.

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A prospective study of 31 cases. Eur J Radiol 82 9: On operation, the gallbladder wall was thickened and the serosa were surrounded by dense fibrous adhesions which were often extensive and attached to the adjacent hepatic parenchyma.

Histopathological study and classification. Dissection between the gallbladder serosa and hepatic parenchyma was difficult. Microscope – Seeing the Unseen.

Pathol Res Pract ; J Indian Med Assoc hitsopathology XGC may be difficult to distinguish clinically from acute or chronic cholecystitis; radiologically, it is difficult to distinguish from gallbladder cancer. Foamy macrophages or macrophages with ceroid, bile xanthogranu,omatous iron Also cholesterol clefts and multinucleated giant cells May be focal, nodular or diffuse May contain lymphocytes, plasma cells, foreign body giant cells and neutrophils.

The pathogenesis of XGC is unclear, although the role of lipid and bile is thought to be important.

Xanthogranulomatous cholecystitis

J Minim Access Surg 9 3: Previous reports have suggested that the important process is the extravasation of bile into the gallbladder wall, either from ruptured Rokitansky-Aschoff sinuses or focal mucosal ulceration 25.


Ultrasonographic examination showed an inhomogenous, hypoechoic wall thickening of the gallbladder with internal small stones and no dilatation of intrahepatic bile ducts Fig. Computed tomogram CT revealed a well-marginated, uniform, marked wall thickening of the gallbladder with multiseptate enhancement. The pathologic findings showed the collection of foamy histiocytes containing abundant lipid in the cytoplasm and admixed lymphoid cells x A case report and review of literature.

Pathology of Xanthogranulomatous Cholecystitis – Dr Sampurna Roy MD

Ann R Coll Surg Engl. Gallstones are present in most cases. On intraoperative cholangiogram through the cystic duct after cholecystectomy, there was no evidence of remaining stone or bile duct dilatation. Clinical manifestations of XGC are usually those of acute or chronic cholecystitis, xanthogeanulomatous some patients present anorexia, nausea, vomiting, right upper quadrant pain and mass, suggesting gallbladder cancer.

Acute cholecystitis ; Acalculous cholecystitis ; Emphysematous cholecystitis ; Eosinophilic Cholescystitis ; Necrobiotic Xanthogranuloma of the the skin.

Young Eun Joo, M. Histologically, the nodules are predominantly composed of abundant lipid-laden macrophages, inflammatory cells and fibroblasts. Cytopathologic diagnosis of xanthogranulomatous cholecystitis and coexistent lesions. Hepatobiliary Pancreat Dis Int. The sections show a thickened gallbladder wall with cholesterol clefts, multinucleated giant cells, fibrosis and small lymphoid aggregates. XGC may be a high risk of postoperative wound choleccystitis and other septic complications cholecystigis of frequent adhesion and abscess formation.


Gallbladder Cholecystitis Xanthogranulomatous cholecystitis Author: A retrospective Cohort study.

A Case of Xanthogranulomatous Cholecystitis

Preoperative diagnosis of xanthogranulomatous cholecystitis. Genetic analysis of xanthogranulomatous cholecystitis: Address reprint requests to: Xanthogranulomatous cholecystitis mimicking gallbladder cancer: Xanthogranulomatous cholecystitis Diagnosis in short Xanthogranulomatous cholecystitis. Acta Pathol Jpn ; The pathologic findings showed the collection of foamy histiocytes containing abundant lipid cholecyxtitis the cytoplasm and admixed lymphoid cells.

Hyperplasia, atypical hyperplasia and carcinoma in situ. Benign tumors and pseudotumors of the gallbladder: A Case of Xanthogranulomatous Cholecystitis.

J Clin Pathol 40 4: The diagnosis is usually possible only after pathological examination. Click here for patient related inquiries. Coagulation profiles were PT Surgical procedures and histopathologic findings for patients with xanthogranulomatous cholecystitis.: Cross sections through the wall revealed multiple yellow-colored, nodule-like lesions ranging from 0.

Xanthogranulomatous cholecystitis. Histopathological study and classification.

This page was last modified on 30 Mayat At operation, there are adhesions to surrounding tissues, and sometimes a mass is found, mimicking tumour of the gallbladder. Therefore, before the operation, differential diagnosis of XGC and gallbladder cancer by percutaneous needle biopsy might be helpful in planning the appropriate operative procedure.

Arch Pathoi Lab Med ;